Advertisement
Advertisement

New in Cell Biology

Cover of the Thematic Minireview Series 2015: Metals at the Host-Pathogen InterfaceThematic Minireview Series 2015:
Metals at the Host-Pathogen Interface

Coordinating Editor: F. Peter Guengerich
 
 

JBC Podcasts icon The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span

In this episode of the JBC Paper of the Week podcast, we interviewed Terra Arnason about a new study on the AMPK UBA domain.

CELL BIOLOGY IN PRESS

Yitian Cai, Boon Heng Dennis Teo, Joo Guan Yeo, Jinhua Lu
First Published on Jul 31, 2015
Wen Lu, Weiqing Fang, Jian Li, Bin Zhang, Qian Yang, Xunyi Yan, Lin Peng, Heng Ai, Jie-jie Wang, Xiao Liu, Jianhong Luo, Wei Yang
First Published on Jul 30, 2015
Tadayuki Akagi, Satu Kuure, Kousuke Uranishi, Hiroshi Koide, Frank Costantini, Takashi Yokota
First Published on Jul 29, 2015
Yongge Zhao, Chi A. Ma, Liming Wu, Kazuhiro Iwai, Jonathan D. Ashwell, Eugene M. Oltz, Dean W. Ballard, Ashish Jain
First Published on Jul 29, 2015
Andrés Tittarelli, Bassam Janji, Kris Van Moer, Muhammad Zaeem Noman, Salem Chouaib
First Published on Jul 28, 2015
Leanna R. Gentry, Akiyuki Nishimura, Adrienne D. Cox, Timothy D. Martin, Denis Tsygankov, Motohiro Nishida, Timothy C. Elston, Channing J. Der
First Published on Jul 27, 2015
Shiuh-Rong Ho, Yu-Ju Lee, Weei-Chin Lin
First Published on Jul 27, 2015

Best of 2014

Richard Linck, Xiaofeng Fu, Jianfeng Lin, Christna Ouch, Alexandra Schefter, Walter Steffen, Peter Warren, Daniela Nicastro
June 20, 2014 The Journal of Biological Chemistry, 289, 17427-17444.

PAPERS OF THE WEEK

Reports

Estifanos N. Habtemichael, Abel Alcázar-Román, Bradley R. Rubin, Laura R. Grossi, Jonathan P. Belman, Omar Julca, Michael G. Löffler, Hongjie Li, Nai-Wen Chi, Varman T. Samuel, Jonathan S. Bogan
First Published on May 05, 2015
Katy J. Petherick, Owen J. L. Conway, Chido Mpamhanga, Simon A. Osborne, Ahmad Kamal, Barbara Saxty, Ian G. Ganley
First Published on Apr 01, 2015

CLASSICS

Alton Meister
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 13, 2007
Daniel E. Koshland
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 07, 2007
Elizabeth F. Neufeld
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on May 11, 2007
Mary Ellen Jones
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on May 04, 2007
Robert T. Schimke
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 20, 2007
Masayasu Nomura
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 30, 2007
John M. Buchanan. Photo courtesy of Protein Science (1).
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Oct 27, 2006
Avram Hershko. Photo courtesy of Technion-Israel Institute of Technology. 
Photographed by Miki Koren.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 29, 2006
Michael Smith
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 22, 2006
Rupert Timpl. Photo reprinted from Ref. 3, published by S. Karger AG, Basel.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 15, 2006
Roger Tsien. Photo by Joe Toreno.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Sep 08, 2006
David Shemin
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Aug 18, 2006
Edward D. Korn
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jul 07, 2006
David H. MacLennan
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jun 16, 2006
Line art representation of a quill pen. Photo credit: Wikimedia Commons: 
http://commons.wikimedia.org/wiki/File:Quill_%28PSF%29.png.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 21, 2006
Stanley Cohen. Photo courtesy of Vanderbilt University.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 03, 2006
Scanning electron micrograph of /Escherichia coli/, grown in culture and 
adhered to a cover slip. Photo credit: Wikimedia Commons: 
http://commons.wikimedia.org/wiki/File:EscherichiaColi_NIAID.jpg.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Dec 23, 2005
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on May 27, 2005
Protoporphyrin 9, taken from Radin /et al/. (1950), /J. Biol. Chem./ *184*, 
755-768.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Apr 08, 2005
Severo Ochoa. Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Mar 11, 2005
Otto F. Meyerhof. Photo courtesy of the National Library of Medicine.
Nicole Kresge, Robert D. Simoni, Robert L. Hill
First Published on Jan 21, 2005
Philip P. Cohen. Photo courtesy of the National Library of Medicine.
Robert D. Simoni, Robert L. Hill, Martha Vaughan, Herbert Tabor
First Published on Dec 24, 2003
Edward A. Doisy. Photo courtesy of the National Library of Medicine.
Robert D. Simoni, Robert L. Hill, Martha Vaughan
First Published on Jul 12, 2002
Frederick G. Hopkins. Photo courtesy of the National Library of Medicine.
Robert D. Simoni, Robert L. Hill, Martha Vaughan
First Published on Jun 07, 2002
Otto Folin
Robert D. Simoni, Robert L. Hill, Martha Vaughan
First Published on May 10, 2002
Christian A. Herter. Photo courtesy of the National Library of
Medicine.
Robert D. Simoni, Robert L. Hill, Martha Vaughan
First Published on Apr 19, 2002
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26

REFLECTIONS

*Imported mitochondrial proteins whose folding to the native form in the 
matrix compartment was deficient in our Hsp60-deficient yeast mutant.* 
Ketoglutarate dehydrogenase (/KGDH/) and lipoamide dehydrogenase (/LPDH/) 
were observed to be affected in Ref. 39. Pre-existent functional Hsp60 was 
observed to be required for proper folding and subsequent assembly of newly 
imported Hsp60 in Ref. 40: no new Hsp60 complex could be produced in the 
mutant yeast after temperature shift. /OM/, outer membrane; /IM/, inner 
membrane; /Fo SUIX/, subunit 9 of F0-ATPase; /F1/β, F1-ATPase β-subunit; 
/CS/, citrate synthase. This figure was modified from Ref. 45.
Arthur L. Horwich
First Published on Jun 26, 2013
*Greg Siskind (from /left/), Harlyn Halvorson, Jacques Monod, Georges Cohen, 
and Len Herzenberg (/front/) in 1956.*
Leonore A. Herzenberg, Leonard A. Herzenberg
First Published on Oct 12, 2012
*Laboratory of Ed Krebs in Davis in 1976.* Shown standing (from left to 
right) are Peter Bechtel, J. L. M., Ed Krebs, Joe Beavo, Bruce Kemp, Toby 
Dills, Yutaka Shizuta, and Jackie Vandenheede. T. S. Huang and Ramji 
Khandelwal are kneeling.
James L. Maller
First Published on May 08, 2012
*Three genetic criteria for a prion of yeast (1).* I proposed that these 
properties are expected of prions but not of nucleic acid replicons (viruses 
or plasmids) and so should allow diagnosis of yeast prions among 
non-chromosomal genetic elements.
Reed B. Wickner
First Published on Mar 06, 2012
*γ-Glutamyl cycle proposed by Alton Meister (12).* The cycle is involved 
primarily in the turnover of glutathione, /i.e./ glutathione synthesis and 
degradation. /AA/, amino acid.
Naoyuki Taniguchi
First Published on Oct 19, 2009
*The mentors during my postdoctoral time.* /a/, Sol Spiegelman with his wife, 
Helen Spiegelman (1958). /b/, J. D. Watson, S. Benzer, and myself (from left 
to right) at a meeting in 1990.
Masayasu Nomura
First Published on Dec 12, 2008
*The multicatenane pathway of chromosome segregation (**3**–**5**).* /Thick 
horizontal arrows/ denote pathways of DNA synthesis that convert gapped or 
nicked DNA circles into covalently closed circles. /Thin vertical arrows/ 
denote pathways of decatenation of the intertwined daughter chromosomes. 
Daughter DNA duplexes are in /blue/ and /red/, whereas parental 
double-stranded DNA is in /green/. The monomeric (completely decatenated) and 
supercoiled daughter circles are also in /green/, as they become parental DNA 
in the next round of replication (/red arrow/). The /A/, /B/, and /C/ 
notations of multicatenated DNA dimers correspond to both circles relaxed 
(nicked or gapped), one circle covalently closed (and therefore supercoiled), 
and both circles covalently closed, respectively. /Numbers/, /e.g. 
A10–A30/, are catenation linking numbers, /i.e./ the levels of intertwining 
of double helices in the topologically linked circles. The theta structures 
(replication intermediates) in /brackets/ are diagrams of thetas in which the 
parental (/green/) DNA is nicked and therefore relaxed as histone-free DNA. 
The indicated multicatenanes such as /B5/, /C3/, /C5/, etc., are not depicted 
explicitly, given their highly “entangled” configurations as free DNA. 
Among the technical innovations in these 1980–1981 studies (3–5) was the 
discovery that hypertonic treatment of SV40-infected green monkey CV1 cells 
arrested replicated chromosomes at the stage of decatenation. During arrest, 
highly intertwined nicked (or gapped) A-type multicatenanes were eventually 
converted (via B-type intermediates) to the equally highly intertwined C-type 
multicatenanes (/C10–C30/), in which both circles were covalently closed 
and supercoiled (/thick dashed arrows/ at the top). The supercoiled state 
stemmed from the presence of nucleosomes in the minichromosomes, prior to 
removal of histones for analyses of DNA topology. Upon release from the 
decatenation block, the highly intertwined C-type multicatenanes were 
decatenated to supercoiled monomers (/vertical dashed arrows/; “recovery 
pathway”). The actual paths taken during chromosome segregation (in the 
absence of decatenation arrest) include the entire matrix of transitions 
shown in the diagram. The relative rates of flow along specific paths depend 
on the rates of gap-filling DNA synthesis (converting a nicked or gapped 
circle into a covalently closed circle) /versus/ the rates of decatenation of 
multiply intertwined chromosomes by topoisomerase II (3, 4).
Alexander Varshavsky
First Published on Aug 15, 2008
Photo courtesy of Vanderbilt University.
Stanley Cohen
First Published on Aug 12, 2008
Prospect of grant request being funded in relation to the originality of the 
research proposal.
Howard K. Schachman
First Published on Feb 03, 2006
Photo credit: Jared Lazarus/Duke Photography.
Wolfgang Karl (Bill) Joklik
First Published on Dec 02, 2005
John B. Gurdon. Photo taken in 2000.
Donald D. Brown
First Published on Aug 12, 2004
The amino acid sequences of caltrins from bull, rat, guinea pig, and mouse.
Henry Lardy
First Published on Dec 18, 2002
John Jacob Abel
Joseph S. Fruton
First Published on Apr 17, 2002
The erythrocyte glycocalyx. This is revealed in electron microscopy by 
special staining methods. It is up to 1400 Å thick, and the oligosaccharide 
filaments are 12–25 Å in diameter. (Taken from Voet and Voet, 
Biochemistry, with permission of the publisher. Original was by courtesy of 
Harrison Latta, UCLA).
Saul Roseman
First Published on Sep 11, 2001
1
2
3
4
5
6
7
8
9
10
11
12
13
14

MINIREVIEWS

Daniel E. Cooper, Pamela A. Young, Eric L. Klett, Rosalind A. Coleman
First Published on Jun 29, 2015
Ali Jazayeri, Joao M. Dias, Fiona H. Marshall
First Published on Jun 22, 2015

Most Read
Last Two Months

Gil Myoung Kang, Yu Mi Han, Hyuk Whan Ko, Joon Kim, Byung Chul Oh, Ijoo Kwon, Min-Seon Kim
First Published on Jun 03, 2015
Alok Sharma, Sozanne R. Solmaz, Günter Blobel, Ivo Melčák
First Published on May 29, 2015

MOST CITED

Liza J. Raggatt, Nicola C. Partridge
First Published on May 25, 2010
Antti Hassinen, Antti Rivinoja, Annika Kauppila, Sakari Kellokumpu
First Published on Apr 08, 2010